Endocrine Abstracts

Introduction: The bone-sparing effect of oestrogen is mediated via oestrogen receptor alpha (ERα), which stimulates transcriptional action through its two activation functions (AF1 and AF2). In addition to these nuclear effects, a fraction of this receptor is targeted to the plasma membrane and triggers membrane initiated steroid signaling (MISS). Whereas, ERα AF1 plays a crucial role in trabecular bone, but not cortical bone, ERα AF2 is necessary for the oestro...